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KMID : 0861020000150010123
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Korea Journal of Herbology
2000 Volume.15 No. 1 p.123 ~ p.128
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Anaphylactic Reaction Inhibitory Effect of Fructus Chebula
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Abstract
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We investigated the effects of methanol extract of Fructus Chebula (MEFC) on local and systemic anaphylaxis. Passive cutaneous anaphylaxis inhibited to 61.42 12.8 % by oral administration of MEFC(I.0 glkg). MEFC inhibited compound 48/80-induced anaphylactic shock 100% with doses of 0.05-1.0 glkg . Administrations of MEFC (1.0 glkg) 60 min before, 5 min after, and 10 min after the compound 48/80 treatment were shown the mortality rates as 0%. MEFC (0.01-1.0 glkg) inhibited the histamine release significantly from the rat peritoneal mast cells by compound 48/80. These results indicate that MEFC inhibits mast cell mediated anaphylactic reactions by inhibition of mast cell degranulation in vivo and in vitro.
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